Research publications

Olson HM, Maxfield A, Calistri NL, Heiser LM, Qian W, Knaut H, Nechiporuk AV. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development. 1;151(1):dev201898. doi: 10.1242/dev.201898

Qian W, Yamaguchi N, Lis P, Cammer M, Knaut H. (2024) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current Biology. 22;34(2):245-259. doi: 10.1016/j.cub.2023.11.044

Yamaguchi N., Zhang Z., Schneider T., Wang B., Panozzo D., Knaut H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature Cell Biology. 24(2):194-204. doi: 10.1038/s41556-022-00844-9

Wang L., Paudyal S.C., Kang Y., Owa M., Liang F.X., Spektor A., Knaut H., Sánchez I., Dynlacht B.D. (2022) Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly. Cell Research. 32(2):190-209. doi: 10.1038/s41422-021-00584-9

Levic D.S., Yamaguchi N., Wang S., Knaut H., Bagnat M. (2021) Knock-in tagging in zebrafish facilitated by insertion into non-coding regions. Development. 148(19). doi: 10.1242/dev.199994.

Kinney B.A., Al Anber A., Row R.H., Tseng Y.J., Weidmann M.D., Knaut H., Martin B.L. (2020) Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition. Cell Reports. doi: 10.1016/j.celrep.2020.108311

Tsai, T. Y-C., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C-P., G Megason, S. G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science. doi: 10.1126/science.aba6637

Lau, S., Feitzinger, A., Venkiteswaran, G., Wang J., Lewellis S.W., Koplinski C.A., Peterson F.C., Volkman B.F., Meier-Schellersheim M.*, Knaut H.* (2020) A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration. Nature Cell Biology. 22(3):266-273 doi.org/10.1038/s41556-020-0465-4

Colak-Champollion, T., Lan, L., Jadhav, A. R., Yamaguchi, Y., Venkiteswaran, V., Patel, H., Meier-Schellersheim, M., Knaut, H.* (2019). Cadherin-mediated cell coupling coordinates chemokine sensing across collectively migrating cells. Current Biology. 29(15):2570-2579.e7. doi: 10.1016/j.cub.2019.06.061

Yamaguchi N, Colak-Champollion T, Knaut H.* (2019) zGrad is a nanobody-based degron system that inactivates proteins in zebrafish. Elife. (2019) Feb 8;8. pii: e43125. doi: 10.7554/eLife.43125. doi: 10.7554/eLife.43125

Schneider JA, Craven TW, Kasper AC, Yun C, Haugbro M, Briggs EM, Svetlov V, Nudler E, Knaut H, Bonneau R, Garabedian MJ, Kirshenbaum K, Logan SK. (2018) Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer. Nature Communications. 9(1):4396. doi: 10.1038/s41467-018-06845-3.

Wang, J, Yin, Y., Lau, S., Sankaran, J., Rothenberg, E., Wohland, T., Meier-Schellersheim M. and Knaut H.* (2018) Anosmin1 shuttles Fgf to facilitate its diffusion, increase signaling and induce sensory organs. Developmental Cell. 46(6):751-766. doi: 10.1016/j.devcel.2018.07.015

Kozlovskaja-Gumbrienė A., Yi R., Alexander R., Aman A., Jiskra R., Nagelberg D., Knaut H., McClain M., Piotrowski T. (2017) Proliferation-independent regulation of organ size by Fgf/Notch signaling. Elife. 6. pii: e21049. doi: 10.7554/eLife.21049.

Fuentes, F., Reynolds, E., Lewellis, S.W., Venkiteswaran, G., Knaut, H.* (2016) A Plasmid Set for Efficient Bacterial Artificial Chromosome (BAC) Transgenesis in Zebrafish. G3. 6(4):829-34. doi: 10.1534/g3.115.026344

Nagelberg, D. Wang, J., Su, R., Torres-Vazquez, J., Targoff, K.L., Poss, K.D. and Knaut, H.* (2015) Origin, specification and plasticity of the great vessels of the heart. Current Biology. 25(16):2099-110. doi: 10.1016/j.cub.2015.06.076

Venkiteswaran, G. Lewellis, S.W. Wang, J. Reynolds, E. Nicholson, C. Knaut, H.* (2013) Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell. 155 (3): 674-687. doi: 10.1016/j.cell.2013.09.046

Lewellis, S.W. Nagelberg, D., Subedi, A. Staton, A. LeBlanc, M. Giraldez, A. Knaut, H.* (2013) Precision in SDF1 cell guidance through ligand clearance and miRNA regulation. Journal of Cell Biology. 200(3):337-55. doi: 10.1016/j.cell.2013.09.046

Staton, A., Knaut, H. and Giraldez, A. J. (2011) miRNA regulation provides genetic robustness to the chemokine signaling pathway during primordial germ cell migration. Nature Genetics. 43(3):204-11. doi: 10.1038/ng.758

reviews

Yamaguchi, N, Knaut H.*(2022) Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo. Development. 149(10). doi: 10.1242/dev.200647.

Wang, J, Knaut, H. * (2014) Chemokine signaling in development and disease. Development. 141(22):4199-205. doi: 10.1242/dev.101071

Lewellis, S.W. and Knaut, H.* (2012) Attractive Guidance: How the chemokine SDF1/CXCL12 guides different cells to different locations. Seminars in Cell and Developmental Biology. 23(3):333-40. doi: 10.1016/j.semcdb.2012.03.009.